Scientific papers

  • Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP. NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe. 2017 Nov 8;22(5):688-696.e5.

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  • Mezzadra R*, Sun C*, Jae LT*, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, Broeks A, Horlings HM, Wessels LFA, Blank CU, Xiao Y, Heck AJR, Borst J, Brummelkamp TR, Schumacher TNM. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017 Sep 7;549(7670):106-110. doi: 10.1038/nature23669. *equal contribution.

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  • Brockmann M*, Blomen VA*, Nieuwenhuis J, Stickel E, Raaben M, Bleijerveld OB, Altelaar AFM, Jae LT#, Brummelkamp TR#. Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature. 2017 May 31. doi:10.1038/nature22376. #corresponding authors

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  • Pillay S*, Meyer NL*, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, and Carette JE. An essential receptor for adeno-associated virus infection. Nature. 2016 Feb 4;530(7588):108-12. *equal contribution.

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  • Baggen J*, Thibaut HJ*, Staring J, Jae LT, Liu Y, Guo H, Slager JJ, de Bruin JW, van Vliet ALW, Blomen VA, Overduin P, Sheng J, de Haan CAM, de Vries E, Meijer A, Rossmann MG, Brummelkamp TR, and van Kuppeveld FJM. Enterovirus D68 receptor requirements unveiled by haploid genetics. PNAS. 2016 Feb 2;113(5):1399-404. *equal contribution.

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  • Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, and Lefeber DJ. Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation. Chemistry & Biology. 2015 Dec 17;22(12):1643-52.

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  • Blomen VA*, Májek P*, Jae LT*, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen F, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, and Brummelkamp TR. Gene essentiality and synthetic lethality in haploid human cells. Science. 2015 Nov 27;350(6264):1092-96. *equal contribution.

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  • Riblett AM*, Blomen VA*, Jae LT*, Altamura LA, Doms RW, Brummelkamp TR, and Wojcechowskyj JA. A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley fever virus infection. Journal of Virology. 2015 Nov 18. pii: JVI.02055-15. *equal contribution.

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  • Kleinfelter LM*, Jangra RK*, Jae LT*, Herbert AS, Mittler E, Stiles KM, Wirchnianski AS, Kielian M, Brummelkamp TR, Dye JM, and Chandran K. Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion. MBio. 2015 Jun 30;6(4):e00801. *equal contribution.

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  • Jae LT, and Brummelkamp TR. Emerging intracellular receptors for hemorrhagic fever viruses. Trends in Microbiology. 2015 Jul;23(7):392-400. Review.

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  • Jae LT, Raaben M, Herbert AS, Kuehne AI, Wirchnianski AS, Soh TK, Stubbs SH, Janssen H, Damme M, Saftig P, Whelan SP, Dye JM, Brummelkamp TR. Lassa virus entry requires a trigger-induced receptor switch. Science. 2014 Jun 27;344(6191):1506-10

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  • Jae LT, Raaben M, Riemersma M, van Beusekom E, Blomen VA, Velds A, Kerkhoven RM, Carette JE, Topaloglu H, Meinecke P, Wessels MW, Lefeber DJ, Whelan SP, van Bokhoven H, and Brummelkamp TR. Deciphering the glycosylome of dystroglycanopathies using haploid screens for Lassa virus entry. Science. 2013 Apr 26;340(6131):479-83.

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